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Phthalates:
Body Burden and Product Testing
Body Burden and Chemicals in Products
|
Problem |
Phthalates
are a common ingredient in many beauty products applied
to the skin and as softeners in a variety of flexible materials
made from PVC. These chemicals and their degradation products
are now ubiquitous in the general population at levels that
are alarming from a public health perspective. |
| Objective
|
To
inform the public about the dangers of phthalates and available
alternatives. There is also some work to encourage manufacturers
to reformulate products to eliminate phthalates. |
|
Monitoring Type |
Monitoring
of chemicals in products and body burden. |
|
Community Involvement |
The
work described did not take place in the context of a specific
community-monitoring project. |
| Notable
Feature |
There
are readily available and cost-competitive alternatives
for the large majority of phthalate uses. |
BACKGROUND: CDC Data Points to Phthalates in Cosmetics
as Serious Concern
In
September 2000, researchers at the Centers for Disease Control
and Prevention (CDC) reported finding seven different phthalates
in the bodies of 289 persons tested for these chemicals, and
that every person tested had a particular phthalate called dibutyl
phthalate, or DBP, in their body. The ubiquity of phthalates
in the general population surprised the scientists: ãFrom a
public health perspective, these data provide evidence that
phthalate exposure is both higher and more common than previously
suspected,ä noted a CDC researcher involved in the study. But
the biggest surprise came when the researchers broke the data
down by age and gender for DBP. They discovered that women of
childbearing age appear to receive the highest levels of exposures
to this phthalate.
CDC
scientists reported that DBP exposures for more than two million
women of child-bearing age may be up to 20 times higher than
that of the average person. Even more significantly, the highest
exposure estimates for women of childbearing age were above
the federal safety standard. The levels of phthalate exposure
in the general population are high enough to raise serious questions
about their safe use in hundreds of consumer products to which
we are regularly exposed.
Because
phthalates have been shown to cause developmental effects in
animals exposed to sufficiently high concentrations, there is
concern for the safety of women of childbearing age who are
being exposed to these compounds. There is also concern for
the children of these exposed women, should these exposure levels
remain high during those months these women are pregnant. These
phthalates can cross over the placental barrier to expose the
developing child. Young, developing organisms are more vulnerable
to exposure to phthalates than adults. In particular, the developing
maleâs reproductive tract appears to be the most sensitive endpoint,
although effects on the liver, kidneys, lungs, and blood clotting
are also of concern.
When
CDC scientists found high levels of DBP in womenâs bodies, they
speculated that cosmetics might be an important source. In a
study published in November 2000, the Environmental Working
Group identified popular nail care products that contain DBP,
including polishes, top coats, and hardeners made by LâOreal,
Maybelline, Oil of Olay, and others. In personal care products,
phthalates provide flexibility, impart an oily ãmoisturizingä
film, and help dissolve and fix other cosmetic ingredients.
The film forming and flexibility properties imparted by phthalates
are also useful in paints, inks, fillers, adhesives and caulks
and insulating properties in electrical cabling and capacitors.
Phthalates are also principal component of flexible PVC products,
pesticides, building maintenance products, lubricants, and a
variety of personal care goods that surround consumers at home,
work, and in hospitals. PVC without additives is inherently
a rigid and brittle material, requiring large amounts of plasticizers
to make flexible products.
Medical
products made from PVC contain between 20% and 80% phthalate
by weight. PVC products that release DEHP, a common phthalate
plasticizer, in the clinical setting include IV storage bags,
ventilator tubing, IV infusion sets, endotracheal tubes, IV
infusion catheters, nasogastric
tubes, blood storage bags, enteral and parenteral nutrition
storage bags and tubing, blood administration sets, urinary
catheters, exam gloves, suction catheters, chest tubes, hemodialysis
tubing, syringes, and cardiopulmonarybypass (CPB) tubing. There
is controversy about the use of phthalates in medical products
because phthalates confer desirable physical properties on these
products. Without DEHP, a wide range of life-saving medical
devices -- such as blood bags, catheters (cardiac and urinary)
and a variety of surgical instruments and gadgets -- would lack
the flexibility, transparency or shelf life to be of much use.
However, there is concern that phthalates could be leaching
from such products and causing exposures that leads to high
body burdens of these chemicals and increases risk for health
effects.
PVC-free
and DEHP-free alternatives are available for almost every use
of PVC in the health care setting, including medical devices,
office supplies, building materials and furnishings. In addition
to medial devices, PVC-free construction and furnishing products
are widely available and are often cost-competitive. Just by
using PVC-free alternatives in construction materials, furnishings,
and furniture products would address roughly 75% of all PVC
use. For more information and links on this topic, refer to:
http://www.noharm.org/pvcDehp/pvcFree.
THE
PROJECT: Testing for Phthalates in Beauty Products
In
May 2002 a coalition of environmental and public health organizations
contracted with a major national laboratory to test 72 name-brand,
off-the-shelf beauty products for the presence of phthalates.
The laboratory found phthalates in nearly three-quarters of
the products
tested (52 of 72 products), including nine of 14 deodorants,
all 17 fragrances tested, six of seven hair gels, four of seven
mousses, 14 of 18 hair sprays, and two of nine hand and body
lotions, in concentrations ranging from trace amounts to nearly
three percent of the product formulation.
The coalition made available this information to the general
public on a website which listed cosmetics that were phthalate
free and those that contained phthalates, so that a concerned
public could make choices about what kinds of products they
wanted to use.
The
network then expanded its campaign to include those chemicals
that the European Union has prohibited from being used as ingredients
in personal care products. These chemicals are prohibited if
they are considered to be carcinogenic, mutagenic or known to
cause reproductive harm. A website www.SafeCosmetics.org
gives a list of safer personal care products and those that
contain known toxicants. The campaign then asked a selection
of the major cosmetic companies to reformulate their products
and several have positively responded, including LâOreal, Revlon,
and Avalon. To obtain the most recent list of safer cosmetics
and the companies that produce them, please consult the website.
REFLECTIONS
ON THE PROJECT
This
campaign is a good example of how a non-geographical community,
linked together by shared concerns for future generations, can
bring about a change in toxic chemical use by combining available
chemical body burden data with product data generated through
independent research.
By identifying body burdens of potentially harmful chemicals
from data generated by the Centers for Disease Control, by identifying
the pathway of exposure through the independent testing of products
for these chemicals, and then by making this information public,
this network was able to persuade major personal care producers
to change their formulation and to offer safer products to a
public eager to buy them. This network was able to accomplish
a change in chemical use practices that would have been very
difficult if not impossible to bring about if the network had
pursued federal legislative initiatives in the United States,
given industry influence on the legislation process.
Raising
funds for product testing and having access to laboratories
and scientists to analyze resulting data can be a problem for
many communities, but as foundations increasingly understand
the value of such campaigns, funds may become more available
in the future.
Contact
information:
http://www.ewg.org/cosmetics/
CDC website with test results: http://www.cdc.gov/exposurereport/phthalates/default.htm
Not too pretty report: http://www.ewg.org/cosmetics/
About phthalates in cosmetics: http://www.nottoopretty.org/
Up-to-date
contact and resource information about phthalates
and other chemicals found in personal care products: http://www.nottoopretty.org/resources.htm
http://www.SafeCosmetics.org
http://womeninenvironment.org
Health
Care Without Harm information on Phthalates in
medical devices:
http://www.noharm.org/pvcDehp/phthalatesDehp
Table
X Phthalates and their metabolites
Phthalate
name
(CAS number) |
Abbreviation |
Urinary
metabolite
(CAS number) |
Diethyl
phthalate
(84-66-2) |
DEP |
Mono-ethyl
phthalate
(2306-33-4) |
Dibutyl
phthalate
(84-74-2) |
DBP |
Mono-n-butyl
phthalate
(131-70-4) |
Benzylbutyl
phthalate
(85-68-7) |
BzBP |
Mono-benzyl
phthalate
(2528-16-7)Some mono-butyl phthalate |
Dicyclohexyl
phthalate
(84-61-7) |
DCHP |
Mono-cyclohexyl phthalate
(7517-36-4) |
Di-2-ethylhexyl
phthalate
(117-81-7) |
DEHP |
Mono-2-ethylhexyl
phthalate
(4376-20-9) |
Di-n-octyl
phthalate
(117-84-0) |
DOP |
Mono-n-octyl
phthalate
(5393-19-1) |
Di-isononyl
phthalate
(28553-12-0) |
DINP |
Mono-isononyl phthalate |
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